Glomerular Leukocyte Infiltration Glomerulonephritis Despite Reduction of Chemokine Antagonists Aggravate CC Chemokine Ligand 5/RANTES
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منابع مشابه
Chemokine and chemokine receptor expression during initiation and resolution of immune complex glomerulonephritis.
Chemokines participate in leukocyte infiltration, which plays a major role in glomerular injury during immune complex glomerulonephritis (IC-GN). Because target cell expression of chemokine receptors (CCR) is thought to mediate leukocyte migration, the expression pattern of chemokines and CCR in a model of IC-GN was examined. The transient course and predominant glomerular pathology of this mod...
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OBJECTIVE Angiotensin II (Ang-II) and mononuclear leukocytes are involved in atherosclerosis. This study reports the inhibition of Ang-II-induced mononuclear cell recruitment by CXCR2 antagonism and the mechanisms involved. METHODS AND RESULTS Ang-II (1 nmol/L, i.p. in rats) induced CXC and CC chemokines, followed by neutrophil and mononuclear cell recruitment. Administration of the CXCR2 ant...
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gesting that, at least in this model, MCP-1 promoted Chemokines are proinflammatory cytokines that funcnearly exclusively tubular epithelial cell damage [5]. tion in leukocyte chemoattraction and activation. There Contrasting with the ample information about chemoare two major families of chemokines, termed CXC and kines and renal injury, so far, little is known about the CC, according to the p...
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Chemokines play a central role in immune and inflammatory responses. It has been observed recently that certain viruses have evolved molecular piracy and mimicry mechanisms by encoding and synthesizing proteins that interfere with the normal host defense response. One such viral protein, vMIP-II, encoded by human herpesvirus 8, has been identified with in vitro antagonistic activities against C...
متن کاملAntagonism of RANTES receptors reduces atherosclerotic plaque formation in mice.
Increasing evidence supports the involvement of inflammation in the early phases of atherogenesis. Recruitment of leukocytes within the vascular wall, controlled by chemokines, is an essential process in the development of this common disease. In this study, we report that blocking a chemokine pathway in vivo with the CC chemokine antagonist Met-RANTES reduces the progression of atherosclerosis...
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